Recommended for use:

Any person presenting with clinical signs or symptoms within a week consistent with acute dengue infection or dengue fever including: high fever, maculopapular rash, myalgia, headaches, vomiting and nausea, and conjunctivitis.

As a subset of the acute clinical symptoms of CHIKV infection are also prevalent in Zika and dengue virus infections that are transmitted by the same mosquito vector, confirmatory diagnosis using real-time PCR is recommended for patients exhibiting clinically compatible symptoms to guide patient management decisions.

CHIKV RNA is detectable in serum up to 7 days post symptom onset. A positive PCR test during this detection window is confirmatory of CHIKV infection. A negative PCR test does not exclude infection as viremia decreases over time and must be followed up with serological testing.